Fitxa persona

JUAN NACHER ROSELLO
PDI-Catedratic/a d'Universitat

juan.nacher@uv.es
http://www.uv.es/nacher
http://nacher.blogs.uv.es

Àrea de coneixement: BIOLOGIA CEL·LULAR
Departament: Biologia Cel·lular, Biologia Funcional i Antropologia Física

(9635) 43241

Asignatures impartides i modalitats docents

33067 - Neurobiologia - Grau en Biologia	Teoria
33159 - Treball fi de grau en bioquímica i ciències biomèdiques - Grau en Bioquímica i Ciències Biomèdiques	Treball fi d'estudis
33824 - Treball fi de grau en Biologia - Grau en Biologia	Treball fi d'estudis
36350 - Neurobiologia i neuropatologia molecular - Grau en Bioquímica i Ciències Biomèdiques	Teoria
40142 - Neurobiologia cel·lular i molecular - Màster Universitari en Neurocièncias Bàsiques i Aplicades	Teoria
40145 - Neurobiologia experimental - Màster Universitari en Neurocièncias Bàsiques i Aplicades	Teoria
40148 - Treball fi de màster - Màster Universitari en Neurocièncias Bàsiques i Aplicades	Treball fi d'estudis

Tutories

Anual

Dilluns de 10:00 a 11:30. DESPATX 2.12.P4.018, EDIF. B, FAC. BIOLÓGIQUES. 4ª PLANTA. PREVIA CONFIRMACIÓ CORREU ELECTRÒNIC

Anual

Dimecres de 10:00 a 11:30. DESPATX 2.12.P4.018, EDIF. B, FAC. BIOLÓGIQUES. 4ª PLANTA. PREVIA CONFIRMACIÓ CORREU ELECTRÒNIC

Observacions

Participa en el programa de tutories electròniques de la Universitat de València

Publicacions en revistes

Bonfanti L, Nacher J. (2012) New scenarios for neuronal structural plasticity in non-neurogenic brain parenchyma: the case of cortical layer II immature neurons. Progress in Neurobiology, 98(1), pp. 1 - 15 . ISSN: 0301-0082
Varea E; Guirado R; Gilabert-Juan J; Martí U; Castillo-Gomez E; Blasco-Ibáñez JM; Crespo C; Nacher J. (2012) Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients. Journal of Psychiatric Research, 46, pp. 189 - 197 . ISSN: 0022-3956
Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E; Zwafink V; Crespo C. (2012) Characterization of a Population of tyrosine hydroxylase-containing interneurons in the external plexiform layer of the rat olfactory bulb. Neuroscience, 217, pp. 140 - 153 . ISSN: 0306-4522
Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E; Lanciego JL; Crespo C. (2012) Two Types of periglomerular cells in the olfactory bulb of the macaque monkey (Macaca fascicularis). Brain Structure & Function, 218(4), pp. 873 - 887 . ISSN: 1863-2653
Gilabert-Juan J, Varea E, Guirado R, Blasco-Ibáñez JM, Crespo C, Nácher J. (2012) Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients. Neuroscience Letters. ISSN: 0304-3940
Hernández S; Gilabert-Juan J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E. (2012) Altered expression of neuropeptides in the primary somatosensory cortex of the Down syndrome model Ts65Dn. Neuropeptides, 46, pp. 29 - 37 . ISSN: 0143-4179
Guirado R; Sanchez-Matarredona D; Varea E; Crespo C; Blasco-Ibanez JM; Nacher J. (2012) Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis. Bmc Neuroscience, 13, p. 5 . ISSN: 1471-2202
J Gilabert-Juan, MD Moltó, J Nácher (2012) Post-weaning social isolation rearing influences the expression of molecules related to inhibitory neurotransmission and structural plasticity in the amygdala of adult rats. Brain Research, 1448, pp. 129 - 136 . ISSN: 0006-8993
Martí-Mengual U, Varea E, Crespo C, Blasco-Ibáñez JM, Nacher J. (2013) Cells expressing markers of immature neurons in the amygdala of adult humans. European Journal of Neuroscience, 37(1), pp. 10 - 22 . ISSN: 0953-816X
Nacher J; Guirado R; Castillo-Gómez E. (2013) Structural plasticity of interneurons in the adult brain: role of PSA-NCAM and implications for psychiatric disorders. Neurochemical Research. ISSN: 0364-3190
Gilabert-Juan J; Castillo-Gomez E; Guirado R; Moltó MD; Nacher J (2013) Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice. Brain Structure & Function, 218(6), pp. 1591 - 1605 . ISSN: 1863-2653
McCall T; Weil ZM; Nacher J; Bloss EB; El Maarouf A; Rutishauser U; McEwen BS (2013) Depletion of polysialic acid from neural cell adhesion molecule (PSA-NCAM) increases CA3 dendritic arborization and increases vulnerability to excitotoxicity. Experimental Neurology, 241, pp. 5 - 12 . ISSN: 0014-4886
Gilabert-Juan J; Belles M; Saez AR; Carceller H; Zamarbide-Fores S; Moltó MD; Nacher J. (2013) A 'double hit' murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus. Neurobiology of Disease, 59, pp. 126 - 140 . ISSN: 0969-9961
Gilabert-Juan J; Nacher J; Sanjuán J; Moltó MD. (2013) Sex-specific association of the ST8SIAII gene with schizophrenia in a Spanish population. Psychiatry Research, 210(3), pp. 1293 - 1295 . ISSN: 0165-1781
Crespo C; Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E. (2013) The Circuits of the Olfactory Bulb. The Exception as a Rule. Anatomical Record-Advances In Integrative Anatomy And Evolutionary Biology, En prensa . ISSN: 1932-8486
Ballestín R; Blasco-Ibáñez JM; Crespo C; Nacher J; López-Hidalgo R; Gilabert-Juan J; Moltó D; Varea E. (2014) Astrocytes of the murine model for Down Syndrome Ts65Dn display reduced intracellular ionic zinc. Neurochemistry International, 75, pp. 48 - 53 . ISSN: 0197-0186
Guirado R; Perez-Rando M; Sanchez-Matarredona D; Castrén E; Nacher J. (2014) Chronic fluoxetine treatment alters the structure, connectivity and plasticity of cortical interneurons. International Journal of Neuropsychopharmacology, 30, pp. 1 - 12 . ISSN: 1461-1457
Tzanoulinou S; García-Mompó C; Castillo-Gómez E; Veenit V; Nacher J; Sandi C. (2014) Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala. Plos One, 9(4), p. e94666 . ISSN: 1932-6203
van der Kooij MA; Fantin M; Kraev I; Korshunova I; Grosse J; Zanoletti O; Guirado R; Garcia-Mompó C; Nacher J; Stewart MG; Berezin V; Sandi C. (2014) Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression. Neuropsychopharmacology, 39(5), pp. 1148 - 1158 . ISSN: 0893-133X
Guirado R; Perez-Rando M; Sanchez-Matarredona D; Castillo-Gómez E; Liberia T; Rovira-Esteban L; Varea E; Crespo C; Blasco-Ibáñez JM; Nacher J. (2014) The Dendritic Spines of Interneurons Are Dynamic Structures Influenced by PSA-NCAM Expression. Cerebral Cortex, 24, pp. 3014 - 3024 . ISSN: 1047-3211
Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E; Lanciego JL; Crespo C. (2015) Synaptic connectivity of the cholinergic axons in the olfactory bulb of the cynomolgus monkey. Frontiers In Neuroanatomy. ISSN: 1662-5129
Lopez-Campos G; Gilabert-Juan J; Sebastia-Ortega N; Gonzalez-Martinez R; Nacher J; Sanjuan J; Molto MD. (2015) Using gene expression and systems biology to interrogate auditory hallucinations in schizophrenic patients. Studies in health technology and informatics, 210, p. 950 . ISSN: 0926-9630
Nacher J; Bonfanti L. (2015) New neurons from old beliefs in the adult piriform cortex? A Commentary on: 'Occurrence of new neurons in the piriform cortex'. Frontiers In Neuroanatomy. ISSN: 1662-5129
Rubio A; Belles M; Belenguer G; Vidueira S; Fariñas I; Nacher J (2015) Characterization and isolation of immature neurons of the adult mouse piriform cortex. Developmental Neurobiology, 229(3), pp. 850 - 857 . ISSN: 1932-8451
Gilabert-Juan J, Sáez AR, Lopez-Campos G, Sebastiá-Ortega N, González-Martínez R, Costa J, Haro JM, Callado LF, Meana JJ, Nacher J, Sanjuán J, Moltó MD. (2015) Semaphorin and plexin gene expression is altered in the prefrontal cortex of schizophrenia patients with and without auditory hallucinations. Psychiatry Research, 229(3), pp. 850 - 857 . ISSN: 0165-1781
Castillo-Gomez E; Coviello S; Perez-Rando M; Curto Y; Carceller H; Salvador A; Nacher J. (2015) Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons. Brain Research Bulletin, 116, pp. 45 - 56 . ISSN: 0361-9230
Hernández-González S; Ballestín R; López-Hidalgo R; Gilabert-Juan J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E. (2015) Altered distribution of hippocampal interneurons in the murine Down Syndrome model Ts65Dn. Neurochemical Research, 40(1), pp. 151 - 164 . ISSN: 0364-3190
Tzanoulinou S; García-Mompó C; Riccio O; Grosse J; Zanoletti O; Dedousis P; Nacher J; Sandi C (2016) Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress. Neuropsychopharmacology, 41(3), pp. 751 - 761 . ISSN: 0893-133X
Castillo-Gómez E; Varea E; Blasco-Ibáñez JM; Crespo C; Nacher J. (2016) Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats. Neural Plasticity, 2016, p. 1615363 . ISSN: 0792-8483
López-Hidalgo R; Ballestín R; Vega J; Blasco-Ibáñez JM; Crespo C; Gilabert-Juan J; Nácher J; Varea E. (2016) Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis. Frontiers In Neuroscience. ISSN: 1662-453X
Javier Gilabert-Juan; Clara Bueno-Fernandez; Esther Castillo-Gomez; Juan Nacher (2016) Reduced interneuronal dendritic arborization in CA1 but not in CA3 region of mice subjected to chronic mild stress. Brain And Behavior. ISSN: 2162-3279
Castillo-Gómez E; Pérez-Rando M; Vidueira S; Nacher J (2016) Polysialic Acid Acute Depletion Induces Structural Plasticity in Interneurons and Impairs the Excitation/Inhibition Balance in Medial Prefrontal Cortex Organotypic Cultures. Frontiers In Cellular Neuroscience, 10, p. 170 . ISSN: 1662-5102
König R; Benedetti B; Rotheneichner P; O' Sullivan A; Kreutzer C; Belles M; Nacher J; Weiger TM; Aigner L; Couillard-Després S (2016) Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?. Frontiers of Biology in China. ISSN: 1673-3509
Carceller H; Rovira-Esteban L; Nacher J; Castren E; Guirado R. (2016) Neurochemical phenotype of Reelin immunoreactive cells in the piriform cortex layer II. Frontiers In Cellular Neuroscience, 10, pp. 1 - 11 . ISSN: 1662-5102
Guirado R; La Terra D; Bourguignon M; Carceller H; Umemori J; Sipilä P; Nacher J; Castrén E. (2016) Efects of PSA removal from NCAM on the critical period plasticity triggered by the antidepressant fluoxetine in the visual cortex. Frontiers In Cellular Neuroscience, 10(22), pp. 1 - 9 . ISSN: 1662-5102
Castillo-Gómez E; Perez-Rando M; Bellés M; Gilabert-Juan J; Llorens JV; Carceller H; Bueno-Fernández C; García-Mompó C; Ripoll-Martínez B; Curto Y; Sebastiá-Ortega N; Moltó MD; Sanjuan J; Nacher J (2017) Early Social isolation stress and perinatal nmda receptor antagonist treatment induce changes in the structure and neurochemistry of inhibitory neurons of the adult amygdala and prefrontal cortex. Eneuro, 4(2), pp. 1 - 23 . ISSN: 2373-2822
Perez-Rando M; Castillo-Gómez E; Guirado R; Blasco-Ibañez JM; Crespo C; Varea E; Nacher J (2017) NMDA Receptors Regulate the Structural Plasticity of Spines and Axonal Boutons in Hippocampal Interneurons. Frontiers In Cellular Neuroscience, 11(166) . ISSN: 1662-5102
Perez-Rando M; Castillo-Gómez E; Bellés M; Carceller H; Nacher J (2017) The activation of NMDA receptors alters the structural dynamics of the spines of hippocampal interneurons. Neuroscience Letters, 658, pp. 79 - 84 . ISSN: 0304-3940
Mulet M; Blasco-Ibañez JM; Crespo C; Nacher J; Varea E (2017) Early increased density of COX-2 immunoreactive neurons in Down Syndrome. Folia Neuropathologica, 55(2), pp. 1 - 7 . ISSN: 1641-4640
Villarroya O; Ballestín R; López-Hidalgo R; Mulet M; Blasco-Ibánez JM; Crespo C; Nácher J; Gilabert-Juan J; Varea E (2018) Morphological alterations in the hippocampus of the Ts65Dn mouse model for Down Syndrome correlate with structural plasticity markers. Histology and Histopathology, 33(1), pp. 101 - 115 . ISSN: 0213-3911
Nacher, J. (2018) Plasticity Molecule Reveals Interneuronal Alterations in Alzheimer's Disease. Neuroscience, 372, pp. 304 - 305 . ISSN: 0306-4522
Perez-Rando M; Castillo-Gomez E; Bueno-Fernandez C; Nacher J. (2018) The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice. Brain Structure & Function, 223(5), pp. 2393 - 2408 . ISSN: 1863-2653
Guirado R; Carceller H; Castillo-Gómez E; Castrén E; Nacher J (2018) Automated analysis of images for molecular quantification in immunohistochemistry. Heliyon, 4(6), pp. 1 - 16 . ISSN: 2405-8440
Carceller H; Perez-Rando M; Castren E; Nacher J; Guirado R. (2018) Effects of the antidepressant fluoxetine on the somatostatin interneurons in the basolateral amygdala. Neuroscience, 386(21 August 2018), pp. 205 - 213 . ISSN: 0306-4522
Rotheneichner P; Belles M; Benedetti B: König R; Dannehl D; Kreutzer C; Zaunmair P; Engelhardt M; Aigner L; Nacher J; Couillard-Despres S. (2018) Cellular Plasticity in the Adult Murine Piriform Cortex: Continuous Maturation of Dormant Precursors Into Excitatory Neurons. Cerebral Cortex, 28(7), pp. 2610 - 2621 . ISSN: 1047-3211
Crespo C; Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E. (2019) Cranial Pair I: The Olfactory Nerve. The Anatomical Record, 302(3), pp. 405 - 427 . ISSN: 0003-276X
Curto Y; Alcaide J; Röckle I; Hildebrandt H; Nacher J. (2019) Effects of the genetic depletion of polysialyltransferases on the structure and connectivity of interneurons in the adult prefrontal cortex. Frontiers In Neuroanatomy, 13(6) . ISSN: 1662-5129
Bellés M; Carbonell J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E (2019) Alterations in reelin and reelin receptors in Down syndrome. Neuroreport. ISSN: 0959-4965
Elena Martínez-Rodríguez; Ana Martín-Sánchez; Simona Coviello; Cristina Foiani; Emre Kul; Oliver Stork; Fernando Martínez-García; Juan Nacher; Enrique Lanuza; Mónica Santos; Carmen Agustín-Pavón (2019) Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system. Brain Structure & Function, 224(4), pp. 1647 - 1658 . ISSN: 1863-2653
Di Forti M; Quattrone D; Moltó MD; Nacher J; Olmeda MS; et al. (2019) The Contibution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. Lancet Psychiatry, 6(5), pp. 427 - 436 . ISSN: 2215-0374
Pesarico AP; Bueno-Fernandez C; Guirado R; Gómez-Climent MÁ; Curto Y; Carceller H; Nacher J. (2019) Chronic Stress Modulates Interneuronal Plasticity: Effects on PSA-NCAM and Perineuronal Nets in Cortical and Extracortical Regions. Frontiers In Cellular Neuroscience, 13(197) . ISSN: 1662-5102
Alcaide J; Guirado; Crespo C; Blasco-Ibáñez JM; Varea E; Sanjuan J; Nacher J. (2019) Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients. International Journal Of Bipolar Disorders, 7(1), p. 24 . ISSN: 2194-7511
Mas S; Gassó P; Rodríguez N; Cabrera B; Mezquida G; Lobo A; González-Pinto A; Parellada M; Corripio I; Vieta E; Castro-Fornieles J; Bobes J; Usall J; Saiz-Ruiz J; Contreras F; Parellada E; Bernardo M; PEPs group. (2019) Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first-episode psychosis cohort. Acta Psychiatrica Scandinavica. ISSN: 0001-690X
Carceller H; Guirado R; Nacher J. (2020) Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood. Journal of Comparative Neurology, 528(8), pp. 1349 - 1366 . ISSN: 0021-9967
Rovira-Esteban L; Hájos N; Nagy GA; Crespo C; Nacher J; Varea E; Blasco-Ibáñez JM. (2020) Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus. Eneuro, ENEURO.0323-19. . ISSN: 2373-2822
Garcia-Mompo C; Curto Y; Carceller H; Gilabert-Juan J; Rodriguez-Flores E; Guirado R; Nacher J. (2020) Δ-9-Tetrahydrocannabinol treatment during adolescence and alterations in the inhibitory networks of the adult prefrontal cortex in mice subjected to perinatal NMDA receptor antagonist injection and to postweaning social isolation. Translational Psychiatry, 10(1), p. 177 . ISSN: 2158-3188
Carceller H; Guirado R; Ripolles-Campos E; Teruel-Marti V; Nacher J. (2020) Perineuronal nets regulate the inhibitory perisomatic input onto parvalbumin interneurons and γ activity in the prefrontal cortex. Journal of Neuroscience, 40(26), pp. 5008 - 5018 . ISSN: 0270-6474
Wakhloo D; Scharkowski F; Curto Y; Javed Butt U; Bansal V; Steixner-Kumar AA; Wüstefeld L; Rajput A; Arinrad S; Zillmann MR; Seelbach A; Hassouna I; Schneider K; Qadir Ibrahim A; Werner HB; Martens H; Miskowiak K; Wojcik SM; Bonn S; Nacher J; Nave KA; Ehrenreich H. (2020) Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nature Communications, 11(1), p. 1313 . ISSN: 2041-1723
Coviello S; Gramuntell Y; Castillo-Gomez E; Nacher J (2020) Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex. Frontiers In Neuroscience. ISSN: 1662-453X
Guirado R; Perez-Rando M; Ferragud A; Gutierrez-Castellanos N; Umemori J; Carceller H; Nacher J; Castillo-Gómez E (2020) A critical period for prefrontal network configurations underlying psyquiatric disorders and addiction. Frontiers In Behavioral Neuroscience, 14(51) . ISSN: 1662-5153
Carbonell J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E (2020) Piriform cortex alterations in the Ts65Dn model for down syndrome. Brain Research. ISSN: 0006-8993
La Rosa C; Cavallo F; Pecora A; Chincarini M; Ala U; Faulkes CG; Nacher J; Cozzi B; Sherwood CC; Amrein I; Bonfanti L (2020) Phylogenetic variation in cortical layer II immature neuron reservoir of mammals. Elife. ISSN: 2050-084X
Mulet M; Blasco-Ibáñez JM; Kirstein M; Crespo C; Nacher J; Varea E. (2020) Phenotypic characterization of MCP-1 expressing neurons in the rat cerebral cortex. Journal of Chemical Neuroanatomy, 106, p. 101785 . ISSN: 0891-0618
Perez-Rando M; Guirado R; Tellez-Merlo G; Carceller H; Nacher J. (2021) Estradiol regulates PSA-NCAM expression and connectivity of O-LM interneurons in the hippocampus of adult female mice. Neuroendocrinology. ISSN: 0028-3835
Vallejo, L; Zapater-Fajarí, M; Montoliu, T; Puig-Perez, S; Nacher, J; Hidalgo, V; Salvador, A (2021) No effects of acute psychosocial stress on working memory in older people with type 2 diabetes. Frontiers In Psychology, 11:596584 . ISSN: 1664-1078
Etxeandia-Pradera JI; Martinez-Uribe D; Bellver-Pradas F; Gonzalez-Piqueras JC; Nacher J; Aguilar EJ. (2021) Training psychiatry residents in descriptive psychopathology: A systematic review. Psychopathology. ISSN: 0254-4962
Pesarico AP; Chagas PM; Nacher J. (2021) Editorial: Animal models of stress - Current knowledge and potential directions. Frontiers In Behavioral Neuroscience, 15, p. 655214 . ISSN: 1662-5153
Casquero-Veiga M; Bueno-Fernandez C; Romero-Miguel D; Lamanna-Rama N; Nacher J; Desco M; Soto-Montenegro ML. (2021) Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity. Scientific Reports, 11(1), p. 5580 . ISSN: 2045-2322
Clara Bueno-Fernandez; Marta Perez-Rando; Julia Alcaide; Simona Coviello; Carmen Sandi; Esther Castillo-Gómez; Juan Nacher (2021) Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice. Neurobiology Of Stress(14) . ISSN: 2352-2895
Coviello S; Benedetti B; Jakubecova D; Belles M; Klimczak P; Gramuntell Y; Couillard-Despres S; Nacher J. (2021) PSA depletion induces the differentiation of immature neurons in the piriform cortex of adult mice. International Journal Of Molecular Sciences. ISSN: 1661-6596
Fernandez Garcia-Agudo L; Steixner-Kumar AA; Curto Y; Barnkothe N; Hassouna I; Jähne S; Butt UJ; Grewe K; Weber MS; Green K; Rizzoli S; Nacher J; Nave KA; Ehrenreich H. (2021) Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Cell Reports, 36(8), p. 109548 . ISSN: 2211-1247
Perez-Caballero L; Carceller H; Nacher J; Teruel-Marti V; Pujades E; Casañ-Pastor N; Berrocoso E (2021) Modulation of wireless effects in implanted electrodes. Effects of implanting insulated electrodes on an animal test to screen antidepressant activity. Journal Of Clinical Medicine, 10(17), p. 4003 . ISSN: 2077-0383
Klimczak P; Rizzo A; Castillo-Gómez E; Perez-Rando M; Gramuntell Y; Beltran M; Nacher J (2021) Parvalbumin interneurons and perineuronal nets in the hippocampus and retrosplenial cortex of adult male mice after early social isolation stress and perinatal NMDA receptor antagonist treatment. Frontiers In Synaptic Neuroscience, 13, p. 733989 . ISSN: 1663-3563
Guirado R; La Terra D; Bourguignon M; Carceller H; Umemori J; Sipilä P; Nacher J; Castrén E. (2016) Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex. Frontiers In Cellular Neuroscience, 10, p. 22 . ISSN: 1662-5102
Curto Y; Garcia-Mompo C; Bueno-Fernandez C; Nacher J. (2016) Chronic benzodiazepine treatment decreases spine density in cortical pyramidal neurons. Neuroscience Letters, 613, pp. 41 - 46 . ISSN: 0304-3940
Rubio A; Belles M; Belenguer G; Vidueira S; Fariñas I; Nacher J (2016) Characterization and isolation of immature neurons of the adult mouse piriform cortex. Developmental Neurobiology, 76(7), pp. 748 - 763 . ISSN: 1932-8451
Sanjuán J; Castro-Martínez XH; García-Martí G; González-Fernández J; Sanz-Requena R; Haro JM; Meana JJ; Martí-Bonmatí L; Nacher J; Sebastiá-Ortega N; Gilabert-Juan J; Moltó MD (2020) FOXP2 expression and gray matter density in the male brains of patients with schizophrenia. Brain Imaging And Behavior. ISSN: 1931-7557
Klimczak P; Rizzo A; Castillo-Gómez E; Perez-Rando M; Gramuntell Y; Beltran M; Nacher J. (2022) Parvalbumin Interneurons and Perineuronal Nets in the Hippocampus and Retrosplenial Cortex of Adult Male Mice After Early Social Isolation Stress and Perinatal NMDA Receptor Antagonist. Frontiers In Synaptic Neuroscience, 13, p. 733989 . ISSN: 1663-3563
Gassó P; Rodríguez N; Martínez-Pinteño A; Mezquida G; Ribeiro M; González-Peñas J; Zorrilla I; Martínez-Sadurni L; Rodriguez-Jimenez R; Corripio I; Sarró S; Ibáñez A; Usall J; Lobo A; Moren C; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Bernardo M; Mas S; 2EPs Group. (2021) A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood. Translational Psychiatry, 11(1), p. 539 . ISSN: 2158-3188
Al-Soufi L; Martorell L; Moltó MD; González-Peñas J; García-Portilla MP; Arrojo M; Rivero O; Gutiérrez-Zotes A; Nácher J; Muntané G; Paz E; Páramo M; Bobes J; Arango C; Sanjuan J; Vilella E; Costas J. (2022) A polygenic approach to the association between smoking and schizophrenia. Addiction Biology, 27(1) . ISSN: 1355-6215
Gramuntell Y; Klimczak P; Coviello S; Perez-Rando M; Nacher J. (2021) Effects of Aging on the Structure and Expression of NMDA Receptors of Somatostatin Expressing Neurons in the Mouse Hippocampus. Frontiers In Aging Neuroscience, 13, p. 782737 . ISSN: 1663-4365
Andreu-Bernabeu Á; Díaz-Caneja CM; Costas J; De Hoyos L; Stella C; Gurriarán X; Alloza C; Fañanás L; Bobes J; González-Pinto A; Crespo-Facorro B; Martorell L; Vilella E; Muntané G; Nacher J; Molto MD; Aguilar EJ; Parellada M; Arango C; González-Peñas J. (2022) Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. Nature Communications, 13(1), p. 51 . ISSN: 2041-1723
Pesarico AP; Carceller H; Guirado R; Coviello S; Nacher J (2022) Long term effects of 24-h-restraint stress on the connectivity and structure of interneurons in the basolateral amygdala. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 115, p. 110512 . ISSN: 0278-5846
Martínez-Pinteño A; Mezquida G; Bioque M; López-Ilundain JM; Andreu-Bernabeu Á; Zorrilla I; Mané A; Rodríguez-Jiménez R; Corripio I; Sarró S; Ibáñez Á; Usall J; Rivero O; Gassó P, Leza JC; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Mas S; Bernardo M; 2EPs Group. (2022) The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study. European Neuropsychopharmacology, 57, pp. 105 - 117 . ISSN: 0924-977X
Pina-Camacho L; Martinez K; Diaz-Caneja CM; Mezquida G; Cuesta MJ; Moreno C; Amoretti S; González-Pinto A; Arango C; Vieta E; Castro-Fornieles J; Lobo A; Fraguas D; Bernardo M; Janssen J; Parellada M; PEPs Group. (2022) Cortical thinning over two years after first-episode psychosis depends on age of onset. Npj Schizophrenia, 8(1), p. 20 . ISSN: 2334-265X
Coviello S; Gramuntell Y; Klimczak P; Varea E; Blasco-Ibañez JM; Crespo C; Gutierrez A; Nacher J. (2022) Phenotype and Distribution of Immature Neurons in the Human Cerebral Cortex Layer II. Frontiers In Neuroanatomy, 16, p. 851432 . ISSN: 1662-5129
Perez-Rando M; Elvira UKA; García-Martí G; Gadea M; Aguilar EJ; Escarti MJ; Ahulló-Fuster MA; Grasa E; Corripio I; Sanjuan J; Nacher J (2022) Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations. Neuroimage-Clinical, 35, p. 103070 . ISSN: 2213-1582
Perez-Rando M; Carceller H; Castillo-Gomez E; Bueno-Fernandez C; García-Mompó C; Gilabert-Juan J; Guirado R; Pesarico AP; Nacher J (2022) Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen. Neurobiology Of Stress, 13(19), p. 100460 . ISSN: 2352-2895
Browne CA; Conant K; Lasek AW; Nacher J (2022) Editorial: Perineuronal Nets as Therapeutic Targets for the Treatment of Neuropsychiatric Disorders. Frontiers In Synaptic Neuroscience, 14, p. 889800 . ISSN: 1663-3563
Rodríguez N; Gassó P; Martínez-Pinteño A; Segura ÀG; Mezquida G; Moreno-Izco L; González-Peñas J; Zorrilla I; Martin M; Rodriguez-Jimenez R; Corripio I; Sarró S; Ibáñez A; Butjosa A; Contreras F; Bioque M; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Bernardo M; Mas S; 2EPS group (2022) Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients. Npj Schizophrenia, 8(1), p. 45 . ISSN: 2334-265X
Carceller H; Gramuntell Y; Klimczak P; Nacher J (2022) Perineuronal Nets: Subtle Structures with Large Implications. Neuroscientist, 23, p. 107385842211063 . ISSN: 1073-8584
Bravo L; Mariscal P; Llorca-Torralba M; López-Cepero JM; Nacher J; Berrocoso E (2022) Altered expression of vesicular glutamate transporter-2 and cleaved caspase-3 in the locus coeruleus of nerve-injured rats. Frontiers In Molecular Neuroscience, 15, p. 918321 . ISSN: 1662-5099

Textos del currículum

Resum de la trajectòria científica. El objetivo principal de mi investigación es el estudio de la plasticidad estructural neuronal en el sistema nervioso central adulto, que incluye remodelación sináptica y de neuritas y neurogénesis adulta. Estamos particularmente interesados en cómo esta plasticidad estructural está involucrada en la etiología de diferentes trastornos psiquiátricos y su tratamiento. Nuestros focos principales son los circuitos inhibidores corticales y la forma polisializada de la molécula de adhesión celular neural (PSA-NCAM) como modulador de su plasticidad. Nuestro grupo descubrió que la expresión de PSA-NCAM en la corteza prefrontal medial está regulada por serotonina (a través de receptores 5HT3) y dopamina (a través de receptores D2), dos monoaminas profundamente implicadas en la etiología y el tratamiento de la esquizofrenia y la depresión y cambios en la expresión de moléculas relacionadas con la neurotransmisión inhibidora También describimos la distribución de las células que expresan PSA-NCAM en la amígdala, la corteza prefrontal medial y otras regiones corticales durante la vida adulta y el envejecimiento y encontramos que la mayoría de estas células eran interneuronas maduras polisializadas exclusivamente por la polisialiltransferasa St8SiaIV. Recientemente descubrimos que la expresión de PSA-NCAM es un regulador crítico de la estructura y conectividad de las interneuronas corticales, especialmente en la inhibición perisomática de las células piramidales.
RESUMEN DEL CV. Catedrático en la Unidad de Neurobiología del ERI BIOTECMED de la Universitat de València (http://www.nacherlab.com), co-IP del G23 de CIBERSAM, investigador asociado a INCLIVA. Doctor en Neurobiología por la Universitat de València, realizó estancia postdoctoral en el laboratorio de Neuroendocrinología de la Universidad Rockefeller en Nueva York (EE.UU). Líneas de investigación sobre la plasticidad del sistema nervioso adulto y su implicación en la etiología y el tratamiento de las enfermedades psiquiátricas. 141 artículos en revistas internacionales, h index: 43. Vicepresidente y secretario de la Sociedad Española de Neurociencia (SENC) (13-17). 2005-2010 Director of the Graduate Program in Basic and Applied Neurosciences, University of València. 2012-2014. Director of the Master in Basic and Applied Neurosciences, University of València. Investigador principal de 6 proyectos I+D de plan nacional y diversos proyectos de comunidad autónoma y fundaciones privadas nacionales e internacionales. IP de nodo nacional de proyecto ERA-NET Neuron. Organizador de eventos de divulgación científica: Pint of science, Brainshake, Neuromascletá, semana del cerebro, @neuronacher en twitter, autor del libro 'La regeneración neuronal' (RBA/National Geographic). Fundador y director científico de la start up biotecnológica Neuropharmatest S.L..