ISMAEL MINGARRO MUÑOZ
PDI-Catedratic/a d'Universitat
PDI-Catedratic/a d'Universitat
Knowledge area: BIOCHEMISTRY AND MOLECULAR BIOLOGY
Department: Biochemistry and Molecular Biology
Department: Biochemistry and Molecular Biology
(9635) 43796
Subjects taught and teaching methods
Tutorials
| First semester |
| Tuesday de 11:30 a 13:00. 2.11.P2.045 |
| Second semester |
| Wednesday de 11:30 a 13:00. 2.11.P2.045 |
| Observations |
| You participate in the electronic tutoring program of the Universitat de València |
Journal Publications
- Duart G.; Lamb J.; Ortiz-Mateu J.; Elofsson A.; Mingarro I. (2022) Intra-Helical Salt Bridge Contribution to Membrane Protein Insertion. Journal of Molecular Biology, 434, pp. 1 - 16 . ISSN: 0022-2836
- Manuel Bañó-Polo*, Luis Martínez-Gil* , Manuel M. Sánchez del Pino , Alberto Massolia , Ismael Mingarro, Rubén Léo, and Maria Jesus Garcia-Murria (2022) Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles. Journal Of Oral Microbiology, 14(2030094) . ISSN: 2000-2297
- Whitley, P.; Grau, B.; Gumbart, J.C.; Martínez-Gil, L.; Mingarro, I. (2021) Folding and insertion of transmembrane helices at the ER. International Journal Of Molecular Sciences, 22(12778) . ISSN: 1422-0067
- Westerfield JM; Sahoo AR; Alves DS; Grau B; Cameron A; Maxwell M; Schuster JA; Souza PCT; Mingarro I; Buck M; Barrera FN. (2021) Conformational Clamping by a Membrane Ligand Activates the EphA2 Receptor. Journal of Molecular Biology, 433(18), p. 167144 . ISSN: 0022-2836
- Duart G; Grau B; Mingarro I; Martinez-Gil L (2021) Methodological approaches for the analysis of transmembrane domain interactions: A systematic review. Biochimica et Biophysica Acta-Biomembranes, 1863(12), p. 183712 . ISSN: 0005-2736
- Duart G; García-Murria MJ; Mingarro I. (2021) The SARS-CoV-2 envelope (E) protein has evolved towards membrane topology robustness. Biochimica et Biophysica Acta-Biomembranes, 1863(7) . ISSN: 0005-2736
- Barriga A; Morán-Lalangui M; Castillo-Sánchez JC; Mingarro I; Pérez-Gil J; García-Álvarez B. (2021) Role of pulmonary surfactant protein Sp-C dimerization on membrane fragmentation: An emergent mechanism involved in lung defense and homeostasi. Biochimica et Biophysica Acta-Biomembranes, 1863(6)(183572), pp. 1 - 11 . ISSN: 0005-2736
- Duart D; Mingarro I; Martinez-Gil L (2021) The importance of transmembrane domain interactions in the viral control of apoptosis. Molecular and cellular oncology, 8(3), p. 1911290 . ISSN: 2372-3556
- García-Murria MJ, Duart G, Grau B, Diaz-Beneitez E, Rodríguez D, Mingarro I, Martínez-Gil L (2020) Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis. Nature Communications, 11(6056) . ISSN: 2041-1723
- Lucendo E, Sancho M, Lolicato F, Javanainen M, Kulig W, Leiva D, Duart G, Andreu-Fernández V, Mingarro I, Orzáez M. (2020) Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis. Proceedings of the National Academy of Sciences of the United States of America, 117(45), pp. 27980 - 27988 . ISSN: 0027-8424
- Gerard Duart*; Mª Jesús García-Murria*; Brayan Grau*; José M. Acosta-Cáceres; Luis Martínez-Gil and Ismael Mingarro (2020) SARS-CoV-2 envelope protein topology in eukaryotic membranes. Open Biology, 10(200209) . ISSN: 2046-2441
- MJ García-Murria; N Expósito-Domínguez; G Duart; I Mingarro; L Martinez-Gil (2019) A Bimolecular Multicellular Complementation System for the Detection of Syncytium Formation: A New Methodology for the Identification of Nipah Virus Entry Inhibitors. Viruses, 11(229) . ISSN: 1999-4915
- Mingarro I. (2019) How do membrane proteins fold?. Biofísica Magazine(13), pp. 1 - 5 . ISSN: 2445-4311
- Manuel Bañó-Polo; Carlos Baeza-Delgado; Silvia Tamborero; Anthony Hazel; Brayan Grau; IngMarie Nilsson; Paul Whitley; James C. Gumbart; Gunnar von Heijne; Ismael Mingarro (2018) Transmembrane but not soluble helices fold inside the ribosome tunnel. Nature Communications, 9(5246), pp. 1 - 9 . ISSN: 2041-1723
- Vera-Velasco NM*; García-Murria MJ*; Sánchez Del Pino MM; Mingarro I; Martinez-Gil L. (2018) Proteomic composition of Nipah virus-like particles. Journal Of Proteomics, 172(17), pp. 190 - 200 . ISSN: 1874-3919
- Christina M. Brock; Manuel Bañó-Polo; Maria J. Garcia-Murria; Ismael Mingarro; Maria Esteve-Gasent (2017) Characterization of the inner membrane protein BB0173 from Borrelia burgdorferi. Bmc Microbiology, 17(219), pp. 1 - 17 . ISSN: 1471-2180
- Luis Martinez-Gil; Natalia Mara Vera-Velasco; Ismael Mingarro (2017) Exploring the Human-Nipah Virus Protein-Protein Interactome. Journal of Virology, 91(23) . ISSN: 0022-538X
- Brayan Grau; Matti Javanainen; Maria Jesús García-Murria; Waldemar Kulig; Ilpo Vattulainen; Ismael Mingarro, Luis Martínez-Gil (2017) The role of hydrophobic matching on transmembrane helix packing in cells. Cell Stress, 1(2), pp. 90 - 106 . ISSN: 2523-0204
- Pastor-Cantizano N; García-Murria MJ; Bernat-Silvestre C; Marcote MJ; Mingarro I; Aniento F. (2017) N-Linked Glycosylation of the p24 Family Protein p24δ5 Modulates Retrograde Golgi-to-ER Transport of K/HDEL Ligands in Arabidopsis. Molecular Plant, 10(8), pp. 1095 - 1106 . ISSN: 1674-2052
- Manuel Bañó-Polo; Carlos A Martínez-Garay; Brayan Grau; Luis Martínez-Gil; Ismael Mingarro (2017) Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit. Biochimica et Biophysica Acta-Biomembranes, 1859(5), pp. 903 - 909 . ISSN: 0005-2736
- Vicente Andreu-Fernández; Mónica Sancho; Ainhoa Genovés; Estefanía Lucendo; Franziska Todt; Joachim Lauterwasser; Kathrin Funk; Günther Jahreis; Enrique Pérez-Payá; Ismael Mingarro; Frank Edlich; Mar Orzáez (2017) Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes. Proceedings of the National Academy of Sciences of the United States of America, 114(2), pp. 310 - 315 . ISSN: 0027-8424
- Poms M; Ansorge P; Martinez-Gil L; Jurt S; Gottstein D; Fracchiolla KE; Cohen LS; Guentert P; Mingarro I; Naider F; Zerbe O. (2016) NMR Investigation of Structures of G-Protein Coupled Receptor Folding Intermediates. Journal of Biological Chemistry. ISSN: 0021-9258
- Ismael Mingarro (2016) La muerte del galgo. Virología, 19(2), pp. 7 - 8 . ISSN: 1133-0384
- Vicente Andreu-Fernández ;María J. García-Murria ; Manuel Bañó-Polo ; Juliette Martin; Luca Monticelli ; Mar Orzáez ; Ismael Mingarro (2016) The C-terminal domains of apoptotic BH3-only proteins mediate their insertion into distinct biological membranes. Journal of Biological Chemistry, 291(48), pp. 25207 - 25216 . ISSN: 0021-9258
- Ismael Mingarro (2016) El fin de la clase media, también en ciencia. Diario El País. ISSN: 1134-6582
- Baeza-Delgado C; von Heijne G; Marti-Renom MA; Mingarro I. (2016) Biological insertion of computationally designed short transmembrane segments. Scientific Reports, 6(23397), pp. 1 - 9 . ISSN: 2045-2322
- Feng Z.; Xue F.; Xu M.; Chen X.; Zhao W.; Garcia-Murria M.J.; Mingarro I.; Liu Y.; Huang Y.; Jiang L.; Zhu M.; Tao X. (2016) The ER-membrane transport system is critical for intercellular trafficking of the NSm movement protein and Tomato Spotted Wilt Tospovirus. PLOS Pathogens, 12(2), pp. e1005443-1 - e1005443-27 . ISSN: 1553-7366
- Peter U. Mayerhofer; Manuel Bañó-Polo; Ismael Mingarro; Arthur E. Johnson (2016) Human peroxin PEX3 is co-translationally integrated into the ER and exits the ER in budding vesicles. Traffic, 17(2), pp. 117 - 130 . ISSN: 1398-9219
- Martínez-Gil L.; Mingarro I. (2015) Viroporins, Examples of the Two-Stage Membrane Protein Folding Model. Viruses, 7(7), pp. 3462 - 3482 . ISSN: 1999-4915
- Pau Doñate-Macian*; Manuel Bañó-Polo*; Jose-Luis Vazquez-Ibar; Ismael Mingarro; Alex Perálvarez-Marín (2015) Molecular and topological membrane folding determinants of transient receptor potential vanilloid 2 channel. Biochemical and Biophysical Research Communications, 462(3), pp. 221 - 226 . ISSN: 0006-291X
- Martínez-Garay, C.A.; Juanes, M.A.; Igual, J.A.; Mingarro, I.; Bañó, M.C. (2014) Transmembrane Serine of Rot1 protein is essential for yeast cell viability. Biochemical Journal, 458, pp. 239 - 249 . ISSN: 0264-6021
- Ana Peiró; Luis Martínez-Gil; Silvia Tamborero; Vicente Pallás; Jesús Sánchez Navarro; Ismael Mingarro (2014) The Tobacco mosaic virus movement protein associates with but does not integrate into biological membranes. Journal of Virology, 88(5), pp. 3016 - 3026 . ISSN: 0022-538X
- Andreu-Fernández V; Genoves A; Lee TH; Stellato M; Lucantoni F; Orzáez M; Mingarro I; Aguilar MI; Pérez-Payá E. (2014) Peptides derived from the transmembrane domain of Bcl-2 proteins as potential mitochondrial priming tools. Acs Chemical Biology, 9(8), pp. 1799 - 1811 . ISSN: 1554-8929
- Whitley P; Mingarro I (2014) Stitching proteins into membranes, not sew simple. Biological Chemistry, 395(12), pp. 1417 - 1424 . ISSN: 1431-6730
- Wood, Elaine; Tamborero Capilla, Silvia; Mingarro Muñoz, Ismael; Esteve Gassent, María D. (2013) BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin Α3Β1. Journal of Bacteriology, 195(15), pp. 3320 - 3330 . ISSN: 0021-9193
- Baeza Delgado, Carlos; Mingarro Muñoz, Ismael (2013) The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild. Bmc Genomics, 14(1), pp. 363- - 363-7 . ISSN: 1471-2164
- Baeza Delgado, Carlos; Marti Renom, Marc A.; Mingarro Muñoz, Ismael (2013) Structure-based statistical analysis of transmembrane helices. European Biophysics Journal With Biophysics Letters, 42(2-3), pp. 199 - 207 . ISSN: 0175-7571
- Manuel Bañó-Polo; Luis Martínez-Gil; Björn Wallner; José L. Nieva; Arne Elofsson; Ismael Mingarro (2013) Charge Pair Interactions in Transmembrane Helices and Turn Propensity of the Connecting Sequence Promote Helical Hairpin Insertion. Journal of Molecular Biology, 425(4), pp. 830 - 840 . ISSN: 0022-2836
- Bañó Polo, Manuel; Baeza Delgado, Carlos; Orzáez Calatayud, María del Mar; Marti Renom, Marc; Abad Mazario, Concepción; Mingarro Muñoz, Ismael (2012) Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing. Plos One, 7(9), p. e44263 . ISSN: 1932-6203
- Lukovic D.; Cruz A.; Gonzalez-Horta A.; Almlen A.; Curstedt T. Mingarro I.; Pérez-Gil J. (2012) Interfacial Behavior of Recombinant Forms of Human Pulmonary Surfactant Protein SP-C. Langmuir, 28, pp. 7811 - 7825 . ISSN: 0743-7463
- Bañó-Polo M; Martínez-Gil L; Barrera FN; Mingarro I. (2020) Insertion of Bacteriorhodopsin helix C into biological membranes. Acs Omega, 5(1), pp. 556 - 560 . ISSN: 2470-1343
- Schaefer KG; Grau B; Moore N; Mingarro I; King GM; Barrera FN. (2021) Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax. Faraday Discussions, 232, pp. 114 - 130 . ISSN: 1359-6640
- Schaefer, KG; Grau, B; Moore, M; Mingarro, I; Gavin King, G; Barrera, F. (2021) Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax. Faraday Discussions, 232, pp. 114 - 130 . ISSN: 1359-6640
Projects
- Membrane Proteins: from basic principles to SARS-CoV-2 (Proyectos de Investigación del Plan Nacional de I+D+I). 2021 - 2024. Ministerio de Ciencia e Innovación. . PI: Ismael Mingarro Muñoz.
- Muerte celular y membranas: un nuevo nicho en la lucha contra el cáncer (Programa Prometeo (GV)). 2019 - 2022. Generalitat Valenciana. . PI: Ismael Mingarro.
- Análisis estructural de las proteínas de membrana del SARS-CoV-2 para el diseño de nuevos inhibidores del ensamblaje viral (). 2020 - 2021. Instituto de Salud Carlos III. . PI: Marçal Vilar.
- Estudio del efecto del CPC -cloruro de cetilpiridinio- en la integridad de las VLP -virus like particles- del SARS-CoV-2 (). 2020 - 2021. Dentaid, S.A.. . PI: Ismael Mingarro.
- Understanding membrane protein folding and biogenesis (Proyectos de Investigación del Plan Nacional de I+D+I). 2016 - 2020. MICINN. . PI: Mingarro Muñoz, Ismael.
- Modulación de interacciones proteína-proteína en apoptosis como diana terapéutica en procesos tumorales (Programa Prometeo (GV)). 2014 - 2017. Generalitat Valenciana. . PI: Ismael Mingarro.
- Instituto Superior de Investigación Cooperativa de Biotecnología y Biomedicina (ISIC BIOTECMED) (). 2013 - 2016. Generalitat Valenciana. . PI: Juan Ferré Manzanero.
- Membrane protein biology (Proyectos de Investigación del Plan Nacional de I+D+I). 2013 - 2015. MICINN. . PI: Mingarro Muñoz, Ismael.
- Ajuda complementaria: Membrane Protein Biology (Conselleria de Cultura, Educació i Ciència de la Generalitat Valenciana). 2014. Generalitat Valenciana. . PI: Ismael Mingarro.
- Identificación de nuevas dianas terapéuticas en angiogénesis y apoptosis basadas en interacciones proteína-proteína (Ajudes Grups d'Investigació). 2010 - 2013. Direcció General de Política científica. Consellería d'Educació. Generalitat Valenciana. . PI: Pérez Payá, Enrique.
Thesis, minor thesis and research reports
- Guillem Tur i Vallés, (2021). Contribución de los residuos flanqueantes cargados en la inserción de hélices transmembrana en células de mamífero. (Final Degree work). Universitat Politècnica de València..
- Grau, Brayan, (2021). Understanding membrane protein folding and interfaciality. (Doctoral Thesis with International Mention). Universitat de València..
- Juan Ortiz Mateu, (2020). Explorando los límites de la inserción en membranas celulares. (Master Thesis). Universitat de València..
- Alberto Tuñón Molina, (2020). Estrategias para la detección y para el diseño de antivirales contra el SARS-CoV-2. (Master Thesis). Universitat de València..
- Carlos Baeza Delgado, (2019). Análisis de la distribución de aminoácidos en regiones flanqueantes de hélices transmembrana. (Working Master or third cycle over 12 credits). Universitat de València..
- Daniel López González, (2019). Proteínas de membrana: topología de NALCN y formación de puentes salinos intramembrana. (Working Master or third cycle over 12 credits). Universitat de València..
- Carlos Baeza Delgado, (2017). On the design of optimally inserted transmembrane helices. (Doctoral Thesis). Universitat de València..
- Carlos A. Martínez Garay, (2016). Estudio de la proteína de membrana de Saccharomyces cerevisiae Rot1: Importancia de su dominio transmembrana. (Doctoral Thesis). València..
- Vicente Andreu Fernández, (2015). Characterizing Bcl-2 family protein domains in membranes: Insertion, interaction and apoptotic modulation roles. (Doctoral Thesis). Universitat de València..
- Patricia Pacios Centeno, (2014). Análisis de las hélices transmembrana monotópicas y politópicas. (Final Degree work). Universitat de València..
Currricul@'s texts
- Webpage. www.uv.es/membrana.
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